Book in PDF format Cardiovascular Toxicology, Edited by Aimen K. Farraj and Matthew J. Campen. About this publication Editor-in-Chief: Charlene A. McQueen; Section Editors: David L. Eaton, Brian N. Chorley, Kathryn E. Page, F. Peter Guengerich, Leigh Ann Burns Naas, Aimen K. Farraj, Matthew Campen, Brian S. Cummings, Christopher A. Reilly, Alessandro Venosa, James Luyendyk, Aileen F. Keating, Sarah Campion, Dana C. Dolinoy, Jason R. Richardson, Lisa Peterson Description Comprehensive Toxicology, Fourth Edition, Fifteen Volume Set continues the legacy that began with the first edition in 1997, serving as an indispensable reference for toxicology researchers. This edition focuses on understanding the mechanisms by which chemicals affect biological systems and cause adverse health effects. Edited by a distinguished editorial board and featuring 400 in-depth contributions from experts around the globe, this comprehensive work spans fifteen volumes and nearly 9,000 pages, covering all major organ systems and general principles of toxicology. This extensively revised edition includes around 30 new chapters on modern testing strategies and novel in vitro models, such as organ-on-a-chip systems. It also explores computational approaches, new risk and safety assessment methods, harmonization, artificial intelligence, and the microbiome. As the most authoritative resource in toxicology, it continues to support researchers, faculty, and students in toxicology, as well as professionals in medical, veterinary, food, environmental, chemical, and pharmaceutical industries and international regulatory agencies. Key Features Covers both the fundamental principles of toxicology and unique aspects of major organ systems Revised edition with new chapters on topics such as new approaches in testing strategies, novel in vitro models such as organ on a chip, and microphysiological systems to name a few Includes computational approaches, ‘omics’, new approaches to risk and safety assessment, harmonization, artificial intelligence, and the microbiome Presents in-depth, comprehensive coverage from an outstanding international author base of domain experts TOC Cardiac Electrophysiology and Pharmacology of Arrhythmia Cardiac Mechanics: The Physiology, Mechanism, and Toxicology of the Heart׳s Function as a Pump Introduction to Vascular Physiology The Role of the Autonomic Nervous System in Cardiovascular Toxicity Measuring Cardiovascular Function in Intact Experimental Models Assessment of Vascular Reactivity Drug Development Using Human iPSC-Derived Cardiomyocytes and Future Perspectives Methods of Analysis: Morphologic Techniques in the Evaluation of the Heart and Blood Vessels Impacts of Environmental Pollutants on Angiogenesis and Vascular Development Oxidative Stress and Heart Failure Oxidants and Endothelial Dysfunction Chronic Vascular Pathology and Toxicology Hypertensive Disorders in Pregnancy and Preeclampsia and the Effect of Environmental Chemical Exposures NSAIDs and Cardiovascular Toxicity Drugs of Abuse and Cardiotoxicity Drug-Induced QT Prolongation Cardiotoxicity Associated With Diabetes Medications Anthracyclines, Trastuzumab, and Cardiovascular Toxicity Influence of Exposure to Bisphenols on Cardiac Structure/Function Metals and Cardiovascular Disease Halogenated Aromatic Hydrocarbons and Cardiovascular Disease Climate Change and Heat Stress Air Pollution Cardiovascular Disease Aldehydes and Cardiovascular Disease Tobacco and Nicotine Delivery Devices: Influences on Cardiovascular Health and Toxicology