In London, Captain Jack Sparrow (Johnny Depp) escapes from the soldiers that are chasing him and learns that an impostor is recruiting a crew and a vessel using his name. He meets the impersonator and finds that she actually is Angelica (Penelope Cruz), a woman that he had seduced in a convent in Seville. Jack is abducted and when he awakens aboard, the ship is sailing, Angelica tells him that her father, the pirate Blackbeard (Ian McShane), is cursed and he needs to find the legendary Ponce de Leon's Fountain of Youth to save his life. They force Jack, who knows the location of the fountain, to guide them. Meanwhile, Captain Hector Barbossa (Geoffrey Rush) is hired by King George (Richard Griffiths) to lead the British crew and dispute against the Spaniards, and Blackbeard, who arrives first to the fountain. But along their dangerous quest, they need to first find two chalices that belonged to Ponce de Leon and a tear of mermaid.